Endocrine Abstracts

Background: Bone metabolism is affected in hemodialysed patients (HD) and PTH plays central role. Additionally leptin which is increased in renal failure may be linked with bone metabolism. We investigated the BMD and bone metabolism in comparison with serum PTH, 25OHD3 and leptin in HD patients.Methods: We measured in 37 HD patients bone alkaline phosphatase (bSAP), NTx, PTH, 25OHD3 and leptin. We evaluated BMI and BMD in lumbar spine (LS) and in femora...

Objective: Thyroglobulin (Tg) production by normal or malignant thyroidal cells is TSH dependent. The rhTSH administration for Tg stimulation in patients with differentiated thyroid cancer (DTC), after thyroidectomy and eradication of thyroid remnants with I-131, offers an alternative to thyroid hormone withdrawal preventing the progressive morbidity of hypothyroidism. Tg measurement is usually obtained on the 3rd and 5th day after the first rhTSH injection.<p class="abste...

Introduction: Among all thyroid nodules 3 to 10% are Hürthle cell (HC) neoplasms classified as either HC adenomas or carcinomas. The presence of capsular or vascular invasion is indicative of a HC carcinoma whose incidence has been found to be 5 to 35%. Hürthle cell carcinoma could also lead to distant metastases and its decreased ability to uptake radioiodine worsens the prognosis. There are reports of histologically characterized HC adenomas with unpredictable clin...

Introduction: Most cases of Diabetes mellitus (DM) in children and adolescents are autoimmune (type 1), even though recently there has been an increase in type 2 DM mainly due to the increased prevalence of obesity in this age group. However, rarely DM could be attributed to other causes such as MODY. An extremely rare cause is the hereditary pancreatitis due to activating mutations of the PRSS1 gene. This gene encodes an enzyme, cationic trypsinogen, whose hyperactivity leads...

Forty-one vitamin D deficient women (aged 26-75 years, mean 56.2, median 57) were treated with Vitamin D3 (50000 IU/week for 1.5 month and 25000 IU/week for another 1.5 month). Before treatment their serum 25(OH)D was 17.3&pm;6.1 ng/ml (mean&pm;SD) and after treatment 37.0&pm;7.5 (P<0.0001). Their HOMA-IR was 2.2&pm;1.1 before and 2.3&pm;1.1 after (P=NS), serum insulin 9.0&pm;4.2 mIU/l before and 9.6&pm;4.5 after (NS), glucose 96.2&pm;8.2 mg/dl before and...

Introduction: Patients with primary hyperparathyroidism (PHPT) present high calcium and PTH levels while some patients present also high PTH levels but normal calcium levels (NHPT) and such patients be considered as having normocalcemic hyperparathyroidism. On the other hand vitamin D deficient patients develop secondary hyperparathyroidism (SHPT). Sometimes normocalcemic- and secondary hyperparathyroidism coexist. Therefore in clinical settings it is very difficult to disting...

Aim: To evaluate the change in PFI (Parathyroid Function Index) and WI (Wisconsin Index) after loading with vitamin D in patients with vitamin D deficiency.Patients and Methods: In 41 vitamin D deficient patients (25(OH)2D<17.16&pm;6.07 ng/ml, mean&pm;SD) the PFI (PTHxCa devided by P) and the WI (PTHxCa) were evaluated before and after 3 month loading with Vitamin D 50.000 IU per week for the first 6 weeks and 25.000 IU per week for the ne...

Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation. The clinical behavior seems to be influenced by the neuroendocrine component. We report a patient with mixed adenoneuroendocrine carcinoma of cecum who presented 18 years after her initial diagnosis and treatment.Case report: A 59-year-old woman presented with a 3-month hist...

Introduction: The clinical profile of patients with primary hyperparathyroidism has changed significantly in the last decades considering the fact that most cases are asymptomatic. This could be attributed to early diagnosis due to routinely serum calcium measurement. Only 5–27% of patients present with symptoms or signs related to osteoporosis, nephrolithiasis and hypercalcaemia. However, in patients with asymptomatic primary hyperparathyroidism (APHP) data concerning t...

BackgroundFollowing the 4th edition of WHO classification of thyroid tumors several pathologic entities were reclassified, mainly as a means of de-escalating addressed therapy. We herein present two rare types of thyroid cancer, hyalinizing trabecular tumor (HTT) and Warthin-like papillary carcinoma (WL-PTC).Cases presentationA 64-year-old female patient presented with an ultrasonographic 1.92 × 1.11 cm ...